Palace won 3-1 in the reverse fixture near the start of the season, with former United midfielder Wilfried Zaha netting twice and Andros Townsend also adding his name to the scoresheet.
Man United enter tonight’s clash in second place in the table, while middling Palace are in 13th. Both sides have won two of their last five fixtures, though United have three draws alongside those victories, while Roy Hodgson’s Eagles have lost two and drawn one of their other matches in that period.
Here’s everything you need to know ahead of tonight’s match.
The game will kick off at 8.15pm this evening.
The match will air live on Sky Sports, with subscribers also able to stream it live on the Sky Sports website and SkyGo app.
Edinson Cavani might not return to full fitness in time for tonight’s game, while Paul Pogba, Juan Mata and Phil Jones also remain out.
For Palace, Zaha will miss out alongside a number of other first-team players, including James McArthur, Connor Wickham, Jeffrey Schlupp, Mamadou Sakho, Wayne Hennessey, Nathan Ferguson and James Tomkins. Nathaniel Clyne could return here, however.
Palace: Guaita; Ward, Kouyate, Cahill, Van Aanholt; Milivojevic, Riedewald; Townsend, Eze, Ayew; Mateta
United: De Gea; Wan-Bissaka, Bailly, Maguire, Telles; Matic, Fred; James, Fernandes, Rashford; Martial
United’s form has waned somewhat in recent weeks but they should rebound here with a win. Palace 1-2 United.