Arsenal have not been beaten by a side starting the day in the relegation zone since they lost 1-0 by West Ham at Emirates Stadium in April 2007. Sheffield United, who are in 19th place, will be hoping to end a six-game winless streak in the Premier League.
Pierre-Emerick Aubameyang is expected to come back in for the Gunners after being rested against Liverpool in the Carabao Cup.
Cedric Soares returned from injury in that match, while Sokratis Papastathopoulos is also back in training but there are still have a number of long-term absentees.
The Blades remain without Simon Moore and Lys Mousset, but John Egan is available fter completing a one-game ban.
He comes back in at right time, too, as fellow defender Jack O’Connell has been ruled out for around six months following knee surgery.
What has been said?
Arsenal manager Mikel Arteta: “We can create a fortress at the Emirates for us.
“It’s going to be crucial for the future results at the end of the season, not just for results but as well for the performance and what we can inspire, what we can transmit at home.
“We want to play with that confidence at home where we have to be really resilient and dominate games to impose ourselves in those games.
“I think the game on Sunday is a really difficult one. I watched Sheffield United’s games already and they deserved much more from those games. The way they played is tricky, so I’m expecting a really difficult game.”
“I always like to see different trends, different ways of playing, formations, structures, patterns and I was impressed with some of the things they were doing. It is always good to have this information.”
Sheffield United boss Chris Wilder: “The players understand the situation they are in, they are as disappointed as me.
“It’s a tough time at the minute, but it doesn’t get any easier if you look at our fixture list.
“I’m not surprised by their reactions after the final whistle and in the changing room. They aren’t jumping through hoops and thinking about what they are going to do later in the day, they are desperately disappointed, but they have to get over that.
“And they will do. The players are up for the fight and in a good place from a mentality point of view, I’m not sensing anyone feeling sorry for themselves.
“It’s a tough time for us at the football club, and I’d imagine the supporters, as it’s not the start we wanted or expected, but we have been through worse periods and it won’t last forever. If you’re tough you will come through it and we will come through it.”