West Ham have gone six Premier League matches without a win, losing four and drawing two.
Tottenham are winless in five league games, their worst spell since a run of six between December 2008 and January 2009.
But it was all change at Spurs this week with Mauricio Pochettino being sacked to make way for Jose Mourinho.
The former Manchester United manager will be determined to hit the ground running against the Hammers.
West Ham vs Tottenham team news
Mark Noble, Michail Antonio and Jack Wilshere are all in contention after training this week.
Manuel Lanzini, though, remains out with a fractured collarbone and joins Lukasz Fabianski on the sidelines.
As for Spurs, Erik Lamela misses out with a hamstring injury.
Hugo Lloris and Michel Vorm remain sidelined with elbow and calf injuries respectively.
Tanguy Ndombele and Jan Vertonghen are doubts to face to the Hammers.
West Ham predicted XI: Roberto; Fredericks, Diop, Ogbonna, Cresswell; Rice, Wilshere; Yarmolenko, Snodgrass, Anderson; Haller.
Tottenham predicted XI: Gazzaniga; Aurier, Sanchez, Dier, Davies; Ndombele, Winks; Sissoko, Alli, Son; Kane.
West Ham vs Tottenham match prediction
Tottenham’s style of play under Mourinho remains an unknown factor.
However, they still have quality players in their squad and they will be keen to impress the new boss.
Predicted scoreline: West Ham 1-2 Tottenham