The last time the two sides met, Spurs saw off the Blues 3-1 at Stamford Bridge.
Mauricio Pochettino’s men will be looking for a similar result this evening, one which would see them leapfrog Chelsea into third place.
But they will go into the match without several of their first-team regulars.
Right-back Kieran Trippier will miss today’s game with a groin problem, an injury which kept him out of England’s matches with the USA and Croatia.
The former Burnley man picked up the injury during Tottenham’s 1-0 victory over Crystal Palace before the international break.
Colombia international Davinson Sanchez will also miss today’s match and may not return to action until the New Year.
“Davinson is still recovering from his injury but he’s doing very well with his recovery, and there are a few other players who are close to coming back and being with the group,” Pochettino said.
“I think now we have a very busy period ahead and it’s so important to start to recover players.”
Spurs will also be without the services of Mousa Dembele and Danny Rose, who are dealing with ankle and groin injuries respectively.
Erik Lamela, Juan Foyth and Paulo Gazzaniga are major doubts following their exploits for Argentina, with Pochettino saying of the trio: “I cannot say nothing because we are assessing the players. They arrived today so early – 6 o’clock in the morning they landed here in London.
“It’s true they don’t rest properly in the last few days, but still today for the game we’re going to try to take the best decisions to try to be close to winning the game. That is in the end our objective.”
Belgium international Jan Vertonghen is once again available for selection following his recovery from a hamstring injury.
The former Ajax man returned to training earlier this week and could start alongside Toby Alderweireld in the heart of Spurs’ defence.
“There’s still one day more but it’s very good news that he’s involved again with the group,” Pochettino said of Vertonghen.
“In the last two weeks he was training very well and now we wait to wait until tomorrow and decide if we believe he can be involved for Saturday.”
Christian Eriksen could be in line for a start following back-to-back starts for Denmark during the international break.
“Always about players that were involved in the World Cup, they suffer some problems so always we try to look after them and provide the best tools to perform. Christian, for different reasons, struggled a little bit in the last month. That’s why we look after them – him and different players too.
“I think he’s best now after the international break… I think to look after him before going to the national team was the best decision because he started in the last 10 days in two games, and to play against Crystal Palace 90 minutes and then start in the last two games with the national team should be too much for him.
“But look, it’s our player and we need to look after our player, to take the best decisions for them.”
Tottenham predicted line up: Lloris; Aurier, Dier, Alderweireld, Davies; Wanyama, Winks; Alli, Eriksen, Lucas; Kane