The Giallorossi – who have just announced that ex-United boss Jose Mourinho will take over from manager Paulo Fonseca at the end of the season – need to overturn a four-goal deficit from the semi-final first leg at Old Trafford.
Despite trailing 2-1 at half time, United went on to win 6-2 thanks to a double apiece for Bruno Fernandes and Edinson Cavani, a header from Paul Pogba and a late strike from Mason Greenwood.
They battered their visitors in Manchester and now have one foot and four toes in the Gdansk final.
Roma did get two away goals through Lorenzo Pellegrini and Edin Dzeko, but it would take a gargantuan effort for them to score four at the Stadio Olimpico.
Even if they did, a goal for United at any stage would likely kill the tie instantly.
Ole Gunnar Solskjaer would no doubt prefer his side to extend their lead early on. Asked about how he plans to approach the game, he said: “We’re not going to play on the result, we’re going to play to win… that’s the only way I think we can play this game.”
One way or another, Roma have to attack and, with United poised to strike on the counter, it should be highly entertaining.
Here’s how to watch…
What time is Roma vs Manchester United?
Kick off is at 8pm on Thursday, March 6, with the game taking place at the Stadio Olimpico in Rome.
The last time United visited the Eternal City was in 2008, with Cristiano Ronaldo and Wayne Rooney scoring the goals in a 2-0 win.
TV channel and live stream details
The game will be shown on BT Sport 3.
Coverage will start from 7.15pm and BT Sport subscribers will also be able to stream the match online via the website or BT Sport app.
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