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New Brazilian mutant Covid strain that may be more contagious found in UK for first time as test blitz launched


A NEW mutant Brazilian strain of Covid that may be more contagious has been found in the UK for the first time with six people infected.

Public Health England confirmed today the Manaus P1 variant has been discovered in three people in England and three in Scotland.

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Six strains of the Brazil variant have been found in the UK

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Six strains of the Brazil variant have been found in the UKCredit: Alamy Live News

It is more contagious and there is a chance it may not respond as well to the jab – although no vaccine data for it exists.

The strain has been described as “of concern” compared to the P2 variant from Brazil that has already been found in the UK.

This is because it shares important mutations with the variant first identified in South Africa.

Three of the people with the new strain were detected on Friday in England, while three were found in Scotland yesterday.

Health officials have identified five of the cases, but an urgent alert has been issued to find the sixth as their identity and whereabouts is unknown.

Two of the other patients are from the same household in South Gloucestershire with surge testing being launched in the area from 9am tomorrow.

PHE said one of the people had travelled back from Brazil and passed on the disease to a family member but they have been isolating.

Their cases were followed up by the PHE Health Protection Team with their contacts identified and re-tested.

One of the cases returned from Brazil

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One of the cases returned from BrazilCredit: Doug Seeburg – The Sun

Two additional people in the same Gloucestershire household have tested positive for Covid, but gene sequencing has not yet confirmed if they have the P.1 variant.

PHE has confirmed there is no wide risk to the community and have asked residents to visit the council’s website for more information.

But the third case has not registered their Covid test online – meaning they have not been identified.

Anyone who took a test on February 12 or 13 but didn’t receive their result or has an uncompleted test registration card is urged to call 119 in England or 0300 303 2713 in Scotland for assistance as soon as possible.

PHE is also urging anyone who flew on Swiss Air flight LX318 travelling from Sao Paulo to London Heathrow via Zurich on February 10 to come forward.

They are hoping to get everyone on the flight and members of their household tested.

Anyone on the flight has been asked to call 0117 450 3174 to arrange a test.

Those returning to the UK should have immediately quarantined at home for 10 days as they arrived before the hotel quarantine rules came into force on February 15.

Residents who live in five postcode areas, who are aged over 16 and do not have symptoms of Covid-19, are invited to come forward for testing from tomorrow.

People who travel into the areas – BS32 0, BS32 8, BS32 9, BS34 5 and BS34 6 – for work or to visit someone they are in a support bubble with are also able to have a test.

There will be drive-in surge testing sites as well as a locations where residents can walk in to collect a test kit to take home and complete, and the programme is expected to run for one week, ending on March 7.

What is the P1 Brazilian variant?

The Brazilian variant (P1) has three key mutations in the spike receptor binding domain (RBD) that largely mirror some of the mutations experts are worried about in the South African variant.

The coronavirus RBD is one of the main targets for our immune defences and also the region targeted by vaccines. Changes within this region are therefore worrisome.

Experts detected the new variant circulating in December in Manaus, north Brazil.

It is not yet known if the mutation causes more severe Covid-19, but evidence suggests it may be more transmissible.

Porton Down scientists are conducting more analysis to confirm evidence that indicates the strain does not cause any higher mortality rate or that it affects the vaccines or treatments.

It was detected in Brazil and in travellers from Brazil to Japan, and contains a unique constellation of lineage defining mutations.

Like the South African variant, the Brazilian one carries a mutation in the spike protein called E484K, which is not present in the UK strain.

The E484K mutation has been shown to reduce antibody recognition, helping the virus to bypass immune protection provided by prior infection or vaccination.

Scientists analysing the Brazilian variant say the mutations it shares with the South African variant seem to be associated with a rapid increase in cases in locations where previous attack rates are thought to be very high.

They say it is therefore essential to rapidly investigate whether there is an increased rate of re-infection in previously exposed individuals.

The Scottish Government said three residents who returned to north-east Scotland from Brazil, via Paris and London, subsequently tested positive for Covid-19.

The tests, completed in early February, were passed to the UK’s sequencing programme and were identified as being the Manaus variant.

Officials are contacting the other passengers on their flight from London to Aberdeen.

The cases are not thought to be connected to the three confirmed cases in England.

Dr Susan Hopkins, PHE strategic response director for COVID-19 and NHS Test and Trace Medical Advisor said: “We have identified these cases thanks to the UK’s advanced sequencing capabilities which means we are finding more variants and mutations than many other countries and are therefore able to take action quickly.

“The important thing to remember is that COVID-19, no matter what variant it is, spreads in the same way.

“That means the measures to stop it spreading do not change. Stay at home and if you do need to go out for essential reasons, cover your nose and mouth, wash your hands thoroughly and keep your distance.

“We ask that individuals come forward for testing through the symptomatic and asymptomatic test sites across the countries in order to continue to drive down cases in the community.”

Scottish Health Secretary Jeane Freeman said: “The identification of this new variant is a concern but we are taking every possible precaution.

“This new variant demonstrates how serious Covid is and reinforces the need to minimise the spread of the virus.”

The World Health Organisation has been informed of the new variant cases.

There are several new variants of Covid which have spread in the UK since the end of 2020.

Boris Johnson forced England into its third national lockdown in January after a more infectious strain of Covid emerged.

The three of most concern emerged in Kent (B1.1.7), South Africa (B.1.351), and Brazil (P.2).

The latest addition, named B.1.525, has similarities to the Kent strain, but with several additional mutations, according to the University of Edinburgh.

Surge testing has been put in place in certain areas in the UK to monitor the spread of the new variants.

But there is evidence stricter measures – including contact tracing and tough border measures – had slowed the spread of the new strains.

Professor Stephen Powis, the NHS’s national medical director, has said coronavirus vaccines can be quickly adapted to tackle new strains, following the emergence of the new Manaus variant which may respond less well to existing immunisations.

He told BBC News: “The new vaccines which are being used for Covid can be adapted very rapidly so it’s likely that if we do need to change the vaccine that can be done in months, rather than years, which was the case with the more traditional vaccines.”

Virologist explains the evolution of the Covid virus and the thousand of variants since the start of the pandemic





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