Mohamed Salah has been struggling with an ankle injury for several weeks.
The Liverpool star did not link up with the Egypt squad over the recent international break, instead remaining in Merseyside to focus on his recovery.
Salah was named on the Reds’ bench at the weekend but he was unused in the 2-1 win over Crystal Palace.
Alex Oxlade-Chamberlain took Salah’s place in the starting line-up and when asked about the decision, Liverpool manager Jurgen Klopp said: “We didn’t know exactly how Mo would come back or how especially Oxlade would come back.
“But Mo, [Friday] was the first session where everything was fine, but it was a bit late then, to be honest. So we decided to bring Ox in a good moment and that’s all. Mo having him here helps a lot, probably for a decisive part of the game, that’s how it is.”
According to Reds team-mate Andy Robertson, Salah was “desperate” to start against Palace but “accepted” Klopp’s decision to rest him.
“Mo was desperate to play as well and the manager made the decision and Mo was fine and accepted it,” Robertson said after the win.
“You don’t want to miss any games but if it means him missing one game rather than six, that is a big difference. Sometimes you need to be a bit clever.
“I have come through, Mo was not needed although he was stripped when Bobby [Roberto Firmino] scored and sat back down. Hopefully that will give him more time to settle and hopefully he will be fine for midweek.”
Will Mohamed Salah play against Napoli?
Leaving Salah on the bench against Palace suggests the star will be involved against Napoli.
It’s an important fixture for the Reds as victory will secure their passage to the Champions League’s last 16.
Salah has been training this week and Klopp is relaxed about the situation.
“Mo looked really good in training. He didn’t do too much but we’ll see. I’m not too worried about it,” said Klopp.
Liverpool were beaten 2-0 when they faced Napoli in Italy earlier in the Champions League group stage.
And Klopp is expecting another tough test when the Serie A outfit arrives at Anfield.
“Napoli are a really dangerous team,” said the German.
“They won against us last year when we were really bad, they won against us this year when we were not so bad, and they gave us a proper fight when they were here. That’s what they will do [on Wednesday].”