The German’s interim tenure got underway with a hard-fought victory against Crystal Palace on Sunday, but it was the short but successful stint of Michael Carrick as caretaker that ensured United of their place in the last-16, with a 2-0 victory over Villarreal.
Rangnick’s vision for United could be seen in glimpses during the first half against the Eagles, and the head coach is likely to take the opportunity against weaker opposition to rotate his squad.
Young Boys sit bottom of the group but still have plenty to play for. The Swiss champions inflicted a shock defeat on United in September and know doing the double could potentially see them still snatch third place in the group.
Here is everything you need to know ahead of the match:
When is it and what time does it start?
The match will get underway at 8pm on Tuesday 8 December at Old Trafford.
How can I watch it online and on TV?
The match will be broadcast live on BT Sport 2 and the BT Sport App, with coverage beginning at 7pm.
What is the team news?
Raphael Varane and Paul Pogba remained ruled out for United, with Edinson Cavani, Luke Shaw, Jesse Lingard and Anthony Martial all doubts. The likes of Donny van de Beek and Mason Greenwood should be given the chance to impress the new coach.
Manchester United: Henderson; Wan-Bissaka, Lindelof, Bailly, Telles; Matic, Van de Beek; Greenwood, Mata, Sancho; Martial
Young Boys: Faivre; Hefti, Burgy, Lauper, Lefort; Aebischer, Martins, Rieder; Elia, Siebatcheu, Ngamaleu
Manchester United – 4/11
Draw – 4/1
Young Boys – 7/1
Despite still transitioning to Rangnick’s playing style, United should have far too much quality for Young Boys, with several squad players keen to take the chance to leave an impression on the new head coach. Manchester United 3-0 Young Boys.