Sheffield United, meanwhile, have one win and four defeats in their last five efforts in the Premier League and are rooted to the bottom of the table on just five points at the exact midway point of their campaign.
Here’s everything you need to know about tonight’s top-flight meeting.
The game will kick off at 8.15pm GMT at Old Trafford.
The match will air live on BT Sport 1 and BT Sport Ultimate. Subscribers can also stream it live on the BT Sport website and app.
Sheffield United could have as many as six absentees, with Oli McBurnie, Sander Berge, Jack Robinson, Jack O’Connell and Ben Osborn among those to be suffering from injuries at the moment. Lys Mousset could return, however.
Man United: De Gea; Wan-Bissaka, Bailly, Maguire, Shaw; Fred, Matic; Greenwood, Fernandes, Martial; Cavani
Sheffield United: Ramsdale; Basham, Egan, Ampadu; Bogle, Lundstram, Norwood, Fleck, Stevens; McGoldrick, Sharp
Man United 3-1 Sheffield United.