Midfielders: Fred, Van de Beek, Fernandes
Scott McTominay made his return from a small injury in the 0-0 draw against Chelsea, but he may not be risked twice in the space of a few days.
Especially with Paul Pogba not expected back until next month, Solskjaer will not want any more injury issues.
Fred will almost certainly play while Bruno Fernandes is arguably the first name on the team sheet every week.
But that leaves an opening for Donny Van de Beek to make just his third league start after recovering from a muscle injury.