Since losing 1-0 on the opening day of the season, Manchester City have not conceded a league goal on their way to three victories.
The Manchester City manager has urged supporters to go to the Etihad Stadium to support their team.
Here is all you need to know about the Premier League fixture.
When is the match?
The game kicks off at 3pm on Saturday 18 September at the Etihad Stadium.
Where can I watch?
The game is not available to watch live in the UK but highlights will be shown on Match of the Day on BBC One on Saturday evening at 10.40pm.
Manchester City have no fresh injury concerns after Wednesday’s Champions League opener, but Pep Guardiola could look to rotate.
A number of his players started both against Leipzig and last weekend against Leicester, but Kevin De Bruyne could start after playing 71 minutes of the meeting with the German side.
Southampton have more to consider – Stuart Armstrong is not yet back in training after his calf issue, while Theo Walcott also has a muscular problem and is expected to miss out.
Young midfielder Will Smallbone could feature in the squad after an extended spell on the sidelines with a serious knee injury, while Ralph Hasenhuttl could persist with a 4-1-4-1 system that worked well defensively against West Ham.
Manchester City: Ederson; Walker, Stones, Dias, Cancelo; Fernandinho, Gundogan, De Bruyne; Sterling, Torres, Jesus
Southampton: McCarthy; Livramento, Stephens, Salisu, Perraud; Romeu; Redmond, Ward-Prowse, Elyounoussi, Djenepo; A. Armstrong
Manchester City – 1/9
Draw – 8/1
Southampton – 17/1
Manchester City should be too strong for Southampton, but don’t rule out Ralph Hasenhuttl finding ways to challenge them having seen his old club RB Leipzig score three against them in the Champions League. Manchester City 3-2 Southampton