Sadio Mane, Mohamed Salah and Roberto Firmino are all set to be rested as Liverpool take on Atalanta tonight.
The trio were rested in the Reds’ last European outing and it would allow the in form Diogo Jota to get a chance to impress from the start.
The summer signing netted the winner against West Ham on Saturday evening and is poised to be joined by Divock Origi and Takumi Minamino.
Klopp continues to juggle several injury problems and Xherdan Shaqiri is set to play in midfield.
The German spoke highly of the 29-year-old’s versatility in the lead up to their trip to Italy.
Centre-half continues to be Liverpool’s most problematic area with Virgil van Dijk a long-term absentee.
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Fabinho is also recovering from an injury which means Joe Gomez could be joined be the returning Joel Matip.
Nathaniel Phillips started at the weekend but is not in the Reds’ Champions League squad while Rhys Williams is another option.
Klopp’s side are currently two from two having secured a win at Ajax before beating FC Midtjylland at Anfield.
Atalanta made the last eight of this competition last term and are two points off the summit in Serie A this season.
They have four points from their opening two fixtures and Klopp is under no illusions of the challenge that lies ahead.
“They obviously have in the team a really good atmosphere in general, a good mood and they are a proper fighting unit. So I was not surprised last year.
“Of course, I didn’t know too much about Atalanta before the [last] season started but I knew about the role they played in Italy, which was the qualification for the Champions League.
“[They are] Difficult to play against, very special in their approach, slightly similar to Leeds, let me say like this, organisation-wise and these kind of things.
“So it will be a tough one.“
Liverpool: Alisson; Alexander-Arnold, Matip, Gomez, Robertson; Shaqiri, Henderson, Milner; Jota, Minamino, Origi
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