Liverpool have enjoyed a flying start to the new campaign, winning all six games in all competitions prior to the Saints’ visit to Anfield.
And Klopp clearly felt confident his side could deal with an alteration in tactics as he gave James Milner a rest and brought Xherdan Shaqiri in.
Summer signing Shaqiri played in a three behind Roberto Firmino as Liverpool switched from a 4-3-3 to a 4-2-3-1.
And Klopp has admitted his team suffered due his decision to shake things up against Southampton – despite their 3-0 win.
“The result is really cool and the performance could have been better,” Jurgen Klopp said.
“The changes cost us as I changed the system.
“Xherdan Shaqiri was influential and Joel Matip was too, but our organisation was a problem.
“You could see that with the communication on the pitch, but we changed back to a system we are used to.
“Saints were not bad, they were really good, but maybe in the final third they were not the biggest threat.
“A clean sheet is very important and staying concentrated in an intense period is difficult.
“Joel Matip was spot on and the full-backs had outstanding work rate and I liked what I saw.
“What I didn’t like today was my fault.”
Klopp suggested battling the elements on Merseyside this week impacted Liverpool’s ability to adapt to the tactical changes he had made.
“My plan was to change tactics but we didn’t have time to train because of the weather in Liverpool,” Klopp told BBC Sport.
“We scored from set pieces, that was really cool, and the second half we had to control the game a bit.
“Winning seven in a row is cool but challenges will get tougher and tougher and we have four days to prepare for [Carabao Cup game against] Chelsea.
“The boys are in good shape and that helps.”
Liverpool follow up Wednesday night’s Carabao Cup clash with Chelsea by facing the Blues in the Premier League on Saturday.