Here is everything you need to know:
The fixture will kick-off at 12pm GMT at the King Power Stadium.
The match is live on BT Sport 1, with coverage starting from 11:30am GMT.
Leicester trio Harvey Barnes, Ricardo Pereira and Timothy Castagne are all set to return to the squad after missing the midweek loss in the Europa League. James Maddison is out due to a hip issue, joining James Justin, Dennis Praet, Ayoze Perez, Wes Morgan and Wesley Fofana on the sidelines.
Thomas Partey returned in the Europa League win over Benfica following his hamstring injury and Rob Holding has recovered from a concussion to give Mikel Arteta a full complement of players.
Leicester City: Schmeichel, Pereira, Evans,Soyuncu, Fuchs, Castagne, Ndidi, Tielemans, Mendy, Barnes, Vardy
Arsenal: Leno, Bellerin, Holding, Mari, Tierney, Partey, Xhaka, Smith Rowe, Odegaard, Aubameyang, Lacazette
Arsenal are on a high – but players like Bukayo Saka surely need a rest. Leicester have been the better side domestically, and the Gunners can never seem to contain Jamie Vardy. I expect the striker to score. 2-1 Leicester.