Both sides will be hoping to kickstart another impressive run of form to reinvigorate their unlikely European pushes, although West Ham may feel they have something of an edge after coming out on top in the pair’s two league meetings last season.
Here is everything you need to know:
When is it and what time is kick-off?
The match will begin at 6pm on Tuesday 29 December.
How can I watch it online and on TV?
The game will be broadcast on Amazon Prime.
New subscribers will be able to watch all the matches for free due to Amazon’s 30-day trial, which can be cancelled at any time. After the trial ends, a subscription will cost £7.99 per month or £79 per year.
Matches can be streamed online and on TV via the Prime Video app, Fire TV, games consoles, BT TV, Apple TV, Virgin’s V6 TV Box, Chromecast, TalkTalkTV and online.
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Danny Ings and Nathan Redmond are both expected to miss out while Jannik Vestergaard is a longer term absentee. Oriel Romeu will return from suspension.
Michail Antonio could finally return from a hamstring injury while Arthur Masuaku will miss out after undergoing knee injury.
Southampton: McCarthy; Walker-Peters, Stephens, Bednarek, Bertrand; Walcott, Ward-Prowse, Romeu, Djenepo; Adams, Long
West Ham: Fabianski; Coufal, Ogbonna, Balbuena, Cresswell, Johnson; Bowen, Rice, Soucek, Fornals; HallerWhat are the odds?