England meet Wales for the first time since Euro 2016 when they go head-to-head at Wembley on Thursday night.
The Three Lions emerged victorious four years ago, winning the game 2-1, though it was Wales who reached the semi-finals while England here humiliatingly dumped out in the second round by Iceland.
Incredibly, this will be the first time England have played at Wembley in 2020.
For Wales, Aaron Ramsey will be absent as he is in “fiduciary isolation” with his Juventus team mates after two members of club staff, neither of whom were players or technical or medical personnel, tested positive for coronavirus.
What time is England vs Wales?
England’s friendly with Wales kicks off at Wembley at 8pm on Thursday.
Both Southgate and Giggs will be using this match to help decide on their starting XIs for their upcoming Nations League games.
England play Belgium and Denmark at Wembley on Sunday and Wednesday, whereas Wales face trips to Ireland and Bulgaria in their group.
England vs Wales TV channel and live stream
England and Wales fans can watch the friendly on ITV.
Coverage begins at 7.30pm and will run through until 10.15pm, and will be available to stream on the ITV Hub app.
Mark Pougatch will present ITV’s coverage, accompanied by analysts Ian Wright, Roy Keane, Chris Coleman and Lee Dixon.
Anyone wanting to watch the match with Welsh commentary can do so on S4C.
England and Wales squads
Goalkeepers: Jordan Pickford, Nick Pope, Dean Henderson
Defenders: Trent Alexander-Arnold, Conor Coady, Eric Dier, Joe Gomez, Michael Keane, Harry Maguire, Ainsley Maitland-Niles, Tyrone Mings, Bukayo Saka, Kieran Trippier, Kyle Walker
Midfielders: Jordan Henderson, Jack Grealish, Mason Mount, Kalvin Phillips, Declan Rice, James Ward-Prowse, Harry Winks
Forwards: Harvey Barnes, Dominic Calvert-Lewin, Danny Ings, Harry Kane, Marcus Rashford, Raheem Sterling
Goalkeepers: Wayne Hennessey, Danny Ward, Adam Davies.
Defenders: Chris Gunter, Ben Davies, Connor Roberts, Ethan Ampadu, Chris Mepham, Joe Rodon, Neco Williams, Ben Cabango, Rhys Norrington-Davies.
Midfielders: Jonathan Williams, Harry Wilson, David Brooks, Joe Morrell, Will Vaulks, Matthew Smith, Dylan Levitt, Brennan Johnson.
Forwards: Hal Robson-Kanu, Daniel James, Kieffer Moore, Tyler Roberts, Ben Woodburn, Rabbi Matondo.
England vs Wales odds
A record-breaking start to the Premier League season has seen an average of 3.79 goals scored per game – a full goal a game more than last season’s average.
Cue an international break … and a Wembley international which threatens to put a dampener on all the excitement.
England and Wales have met only five times this century – and those meetings have produced a grand total of nine goals.
And the last two matches involving Gareth Southgate’s side have ended 0-0 and 1-0, while Wales haven’t scored more than twice in a game since beating Ireland in September 2018.
But if there are going to be goals, Dominic Calvert-Lewin is a great price to mark his full international debut by scoring one of them.
The Everton striker is 15/4 to score first something he has managed in his last three starts against Premier League opposition and a feat he has achieved in three of his four Premier League starts this term.
Odds collected from thepools.com and are subject to change.