Mr Johnson made the comments during Wednesday’s Prime Minister’s Questions.
It comes after the UK surpassed the grim milestone of 100,000 coronavirus deaths. Labour leader Sir Keir Starmer pressed the PM for an answer on why the death toll was so high.
Mr Johnson told the Commons: “I must tell [Sir Keir] there are no easy answers – perpetual lockdown is no answer.”
The PM said they would do “everything” they can to roll-out the vaccine programme, adding: “6.9 million people in our country have had the vaccine. We are on target, if we can get the supplies, to deliver the target of the JCVI one to four most vulnerable groups by the 15th of February.
“And I hope very much to be, in the next few weeks, to be setting out in much more detail how this country can exit now from the pandemic.”
During a sombre press conference on Tuesday evening, Johnson said he took “full responsibility” for every action his Government took and insisted they had done “everything we could” to limit the fatalities.