The BBC anchor will be joined by leading figures in Whitehall as well as Brexit Party MEP and Chairman Richard Tice. The chief of Nigel Farage’s eurosceptic party, is set for a showdown with ardent Remainer’s including Ian Blackford, leader of the SNP at Westminster, Emily Thornberry, shadow foreign secretary and Liberal Democrat MP Layla Moran. The face-off on the BBC’s flagship current affairs programme will be the first time Mr Tice has come head-to-head with Remainers since Parliament voted to stop a no deal Brexit on October 31.
The expected heated panel will be completed by Brexit minister Kwasi Kwarteng and radio host and political commentator Iain Dale.
The Brexit Party chairman has not minced his words since opposition MPs and Tory rebels ensured the bill to stop Britain leaving without an agreement was passed.
On Thursday MPs defeated the Government and voted 327 to 299 in favour of the motion.
The bill, if passed through the House of Lords, will force the Prime Minister to ask the EU for a third extension to Article 50, expected until January 31.
Mr Tice has branded the coup by Remainers in the House of Commons “utterly contemptible”.
MPs further tied the Governments hands and rejected Boris Johnson’s call for a general election to break the Brexit impasse.
The Commons voted 298 to 55 – 136 short of the number needed for another election under the fixed term parliament act.
Mr Tice has branded the Labour Party “hypocrites” and called for change in Westminster.
In a scathing assessment, Mr Tice wrote on Twitter: “The antics we have seen in Westminster these past few days are utterly contemptible.
“The Labour party are hypocrites. They have tried to rig democracy in Westminster but refuse a general election.
“Have the courage of your convictions and face the people.
“Time for change.”
Labour abstained from the vote and insisted it would only entertain a general election once the legislation to stop no deal has been granted royal assent.
Mr Tice is set to clash with Ms Thornberry who attended a People’s Vote rally in Parliament Square yesterday and called for the public to have another vote on Brexit.
Outspoken Remainer, Mr Blackford will also be challenged by Mr Tice, the SNP leader said parliament voted in the “national interest” to stop a no deal Brexit, during a point of order following the result.
He also criticised Mr Johnson for labelling the motion a “surrender bill” and vowed to further thwart Brexit and “bring down this Government”.
Mr Blackford said: “The Prime Minister shouldn’t be talking about surrender.
“He should be congratulating Members of Parliament that have stood up for all our national interest and, really, what a disgrace for a prime Minister to accuse Parliamentarians – decent Parliamentarians of surrender. It simply lacks dignity.”
Mr Blackford said MPs from across the House should come together to “bring down this Government, not on the Prime Minister’s terms, but on the right terms”.
Meanwhile ahead on the looming general election, Mr Tice is likely to face questions on a potential pact with the Tories.
Mr Johnson has so far ruled out any deal with the Brexit Party but is now Governing without a majority in parliament.
Mr Farage has stated the Tories and Brexit Party would be “unstoppable” at an election.
He told the BBC: “If you put the support of Boris Johnson Conservatives and the Brexit Party together, the truth is, in a general election with a clear policy, we would be unstoppable.”
Question Time is on BBC One tonight at 10.35pm.