It was the Blades’ first league win of the season and it heaped an immense amount of pressure on Newcastle manager Steve Bruce.
Here’s everything you need to know about the match.
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The fixture will kick-off at 8pm GMT at the Emirates Stadium.
The match is live on Sky Sports Premier League and Main Event, with coverage starting from 7pm GMT. Subscribers can also stream the match via the Sky Go app.
If you’re not a Sky customer you can grab a NOWTV Day Pass here to watch without a subscription.
Arsenal will be without Pablo Mari, who missed the draw with Palace due to a calf injury. Gabriel Martinelli and Kieran Tierney will be assessed ahead of the clash.
Steve Bruce is hopeful that both Jamal Lewis and Jonjo Shelvey could return from knee and groin issues respectively, but Ryan Fraser is suspended following his sending off at Sheffield United. Jamaal Lascelles will be assessed as he continues his recovery from Covid-19.
Arsenal: Leno, Bellerin, Holding, Luiz, Tierney, Partey, Xhaka, Saka, Smith Rowe, Aubameyang, Lacazette
Newcastle: Darlow, Yedlin, Schar, Clark, Dummett, Longstaff, Hayden, Hendrick, Almiron, Joelinton, Wilson
Both sides are in worrying form, and their FA Cup clash didn’t exactly set pulses racing. However, Newcastle are in a really bad run under Bruce, and it wouldn’t be a surprise if Arsenal nicked a truly scrappy game. 1-0 Arsenal.